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dc.contributor.author |
KADRI Isra, SEMMADI Kaouther |
|
dc.date.accessioned |
2025-07-15T09:55:48Z |
|
dc.date.available |
2025-07-15T09:55:48Z |
|
dc.date.issued |
2025-06-03 |
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dc.identifier.uri |
http//localhost:8080/jspui/handle/123456789/12900 |
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dc.description.abstract |
Acetamiprid (ACE), a widely used neonicotinoid pesticide, is effective in pest control but raises
health and environmental concerns due to its potential toxicity to non-target organisms like
mammals. This study investigated ACE's repercussions on stress parameters in rats and the
protective effects of Juniperus phoenicea L. (JNP) extract against pesticide-induced
neurotoxicity in Albino-Wistar rats.
28 female rats were divided into four groups: control (C), (JNP) extract alone, exposed (ACE),
and a combination of (JNP+ACE). The 30-day oral gavage treatment involved 20mg/kg/day of
ACE and 200mg/kg/day of JNP decoction. Behavioral assessments (open field, elevated plus
maze, forced swim tests) analyzed anxiety, depressive-like behavior, and locomotor activity.
Oxidative stress markers glutathione (GSH), glutathione S-transferase (GST), catalase (CAT),
and protein levels were measured in brain tissue.
Findings showed ACE exposure reduced body and brain weight, increased anxiety and
depressive-like behaviors, and disrupted oxidative balance. This was evidenced by decreased
GSH and GST, and elevated CAT activity, indicating oxidative stress and neuronal damage.
Crucially, co-administering JNP extract ameliorated these behavioral and physiological
impairments.
This study suggests Juniperus phoenicea possesses therapeutic potential as a natural agent
against pesticide toxicity. It emerges as a promising phytotherapy candidate for enhancing
neurological functions and mitigating oxidative stress. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
University of Echahid Cheikh Larbi Tébessi -Tébessa |
en_US |
dc.subject |
Acetamiprid, Juniperus phoenicea L., Oxidative stress, Neurotoxicity, Antioxidants, Biochemical parameters, Stress parameters. |
en_US |
dc.title |
Evaluation of the antioxidant effect of extracted Juniperus Phoenicia L. on the neurotoxicity induced by Acetamiprid pesticide exposure in rats. |
en_US |
dc.type |
Thesis |
en_US |
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