Résumé:
Acetamiprid is a neonicotinoid insecticide known for its rapid efficacy in controlling
insect populations. However, it poses a risk in terms of residue accumulation in agricultural
products, raising concern about its potential effects on human health, including nephrotoxicity.
In our studies, we aimed to evaluate the value and relevance of Juniperus phoenicea as a
therapeutic alternative against acetamiprid-induced toxicity. To minimize its risk to human
health.
twenty-eight female Albino Wistar rats were divided into 4 groups of 7 rats each. The
animals were treated with acetamiprid at a dose of 20 mg/kg per day or an aqueous extract of
Juniperus phoeniceas at a dose of 200 mg/kg orally for 30 days.
The analysis of the results showed that acetamiprid causes adverse effects in the body
leading to decreased nutritional capacity, loss of appetite, and decreased relative weight in rats
and increased relative weight of the kidneys. Relative change in the biochemical parameter
(decreased in albumin,eGFR and increased in uric acid, urea, and creatinine)and significant
changes in antioxidant levels in the kidneys where we observed a decrease in glutathione S-
transferase (GST), a decrease in glutathione (GSH), and an increase in catalase (CAT) activity
Nonetheless, the addition of Juniperus phoenicea improved the observed parameters. This
improvement demonstrates the antioxidant, anti-inflammatory, and therapeutic characteristics
of these medicinal plants in mitigating the disruptive and oxidative effects of acetamiprid.
