Study of the potential protective effects of medicinal plants extract on kidney function impairment caused by insecticide exposure in rats

Abstract

Acetamiprid is a neonicotinoid insecticide known for its rapid efficacy in controlling insect populations. However, it poses a risk in terms of residue accumulation in agricultural products, raising concern about its potential effects on human health, including nephrotoxicity. In our studies, we aimed to evaluate the value and relevance of Juniperus phoenicea as a therapeutic alternative against acetamiprid-induced toxicity. To minimize its risk to human health. twenty-eight female Albino Wistar rats were divided into 4 groups of 7 rats each. The animals were treated with acetamiprid at a dose of 20 mg/kg per day or an aqueous extract of Juniperus phoeniceas at a dose of 200 mg/kg orally for 30 days. The analysis of the results showed that acetamiprid causes adverse effects in the body leading to decreased nutritional capacity, loss of appetite, and decreased relative weight in rats and increased relative weight of the kidneys. Relative change in the biochemical parameter (decreased in albumin,eGFR and increased in uric acid, urea, and creatinine)and significant

changes in antioxidant levels in the kidneys where we observed a decrease in glutathione S- transferase (GST), a decrease in glutathione (GSH), and an increase in catalase (CAT) activity

Nonetheless, the addition of Juniperus phoenicea improved the observed parameters. This improvement demonstrates the antioxidant, anti-inflammatory, and therapeutic characteristics of these medicinal plants in mitigating the disruptive and oxidative effects of acetamiprid.